Status:
COMPLETED
Work of Breathing in Bronchiolitis Under Non-invasive Ventilation
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
URC-CIC Paris Descartes Necker Cochin
Conditions:
Severe Viral Bronchiolitis
Eligibility:
All Genders
Up to 6 years
Phase:
NA
Brief Summary
Severe acute viral bronchiolitis is the leading cause of pediatric intensive care admission. The first-line recommended ventilation support is continuous positive airway pressure (CPAP), which reduces...
Detailed Description
Severe acute viral bronchiolitis is the leading cause of pediatric intensive care admission. The first-line recommended ventilation support is non invasive ventilation (NIV) with continuous positive a...
Eligibility Criteria
Inclusion
- Clinical and radiological diagnosis of bronchiolitis
- Need for non-invasive ventilation support (NiPPV or CPAP) with a modified Wood clinical asthma score (m-WCAS)\> 4 and / or hypercapnic acidosis (pH \<7.3 and / or pCO2\> 50mmHg)
- Written parental informed consent
Exclusion
- Contraindication to nasogastric tube (recent surgery of the esophagus, esophageal malformation at risk of perforation, severe coagulopathy)
- Absolute or relative contraindication to NIV
- Respiratory collapse: coma (GCS \<12) and / or more than 3 apneas per hour with bradycardia \<90 / min and / or SpO2 \<90%
- Pneumothorax
- Preexisting disorder that may influence WOB
- Neuromuscular disease
- Chronic respiratory failure already under NIV or tracheostomy at home
- No social security
Key Trial Info
Start Date :
January 5 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 8 2022
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04677556
Start Date
January 5 2021
End Date
January 8 2022
Last Update
September 15 2025
Active Locations (1)
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1
Hôpital Necker-Enfants Malades
Paris, France, 75015