Status:
COMPLETED
Postoperative Consequences of Intraoperative NOL Titration
Lead Sponsor:
The Cleveland Clinic
Conditions:
Anesthesia; Adverse Effect
Eligibility:
All Genders
21-85 years
Phase:
PHASE3
Brief Summary
To demonstrate that intraoperative NOL-guided titration of fentanyl improves initial recovery characteristics.
Detailed Description
Previous work has shown that NOL (Nociception Level) accurately quantifies nociception during general anesthesia.6 Presumably, titrating opioids to NOL will therefore provide individual guidance so th...
Eligibility Criteria
Inclusion
- Adults having major non-cardiac surgery expected to last ≥2 hours
- American Society of Anesthesiologists physical status 1-3
- Age 21-85 years old
- Planned endotracheal intubation
Exclusion
- Planned neuraxial or regional block
- Clinician preference for an opioid other than, or in addition to, fentanyl
- Non-sinus heart
- Neurologic condition that, in the opinion of the investigators, may preclude accurate assessment of postoperative pain and nausea
- Lack of English language fluency
- Routine user of psychoactive drugs other than opioids
- Contraindication to sevoflurane, fentanyl, morphine, or ondansetron.
- Intracranial surgery.
- BMI \> 40
Key Trial Info
Start Date :
December 30 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 10 2023
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT04679818
Start Date
December 30 2020
End Date
January 10 2023
Last Update
June 21 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Cleveland Clinic
Cleveland, Ohio, United States, 44195