Status:
UNKNOWN
Defining the Severe Paediatric Asthma Endotype
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Severe Asthma
Eligibility:
All Genders
Up to 12 years
Phase:
NA
Brief Summary
The primary objective of this project is to extensively characterize the endotypes of pre-schoolers (0 to 6 years) and school-age children (6 to 12 years) with SA using an integrated approach, combini...
Detailed Description
Asthma is a chronic disease affecting approximately 235 million people worldwide, and the number is rising. Asthma is not just a public health problem for developed countries; its incidence is also el...
Eligibility Criteria
Inclusion
- Patient Inclusion Criteria:
- Minors aged 0 to 6 years or 6 to 12 years, hospitalized for assessment of Severe Asthma
- Minors need with his follow-up an bronchial endoscopy with realization of LBA and biopsies of bronchial mucosa
- Social insurance affiliation, except AME
- Parents or legal guardians signed the Informed consent form
- Control Inclusion Criteria:
- Minors aged 0 to 6 years or 6 to 12 years, hospitalized for assessment of severe respiratory syndrome except severe asthma
- Minors need with his follow-up an bronchial endoscopy with realization of LBA and biopsies of bronchial mucosa
- Social insurance affiliation, except AME
- Parents or legal guardians signed the Informed consent form
- Patient Exclusion Criteria
- Prematurity (\<37 weeks gestation)
- Broncho-pulmonary dysplasia, immune deficits, non-Severe Asthma bronchopathies, cystic fibrosis, heart disease, ongoing biotherapy
Exclusion
Key Trial Info
Start Date :
June 15 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2025
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT04680117
Start Date
June 15 2021
End Date
January 1 2025
Last Update
October 31 2022
Active Locations (1)
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1
Name: Hôpital Necker-Enfants Malades
Paris, France, 75015