Status:
COMPLETED
Defining the Decline in Endogenous Insulin Secretion in Type 1 Diabetes Diagnosed After 30 Years of Age.
Lead Sponsor:
Royal Devon and Exeter NHS Foundation Trust
Conditions:
Diabetes Mellitus, Type 1
Progression
Eligibility:
All Genders
18+ years
Brief Summary
The study aims is to find out if people with type 1 diabetes diagnosed in later life (after age 30) have the same rapid loss of insulin secretion (measured using C-peptide) that occurs in younger adul...
Detailed Description
The study aims to evaluate progression of type 1 diabetes. Primary analysis will be conducted on those with \>=1 diabetes autoantibody positive (GAD, IA2 ZNT8). Sensitivity analysis will be performed ...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Adults with a clinical diagnosis of Type 1 diabetes within the previous 100 days.
- Aged \>30 at the time of Type 1 diabetes diagnosis OR (additional early onset Type 1 diabetes cohort) aged ≥18 and ≤30 at the time of Type 1 diabetes diagnosis.
- Insulin treated at the time of recruitment
- Able and willing to provide informed consent.
- Exclusion criteria
- Pregnancy
- Known monogenic diabetes
- Known secondary diabetes (diabetes considered likely due to medication, cystic fibrosis, pancreatitis, pancreatic cancer, pancreatic surgery, hemochromatosis or Cushing's syndrome).
Exclusion
Key Trial Info
Start Date :
November 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2023
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT04682457
Start Date
November 1 2019
End Date
December 31 2023
Last Update
June 4 2024
Active Locations (1)
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1
Royal Devon & Exeter NHS Foundation Trust
Exeter, Devon, United Kingdom, EX2 5DW