Status:

RECRUITING

The Effect of Different Low-Level Tragus Stimulation Parameters On Autonomic Nervous System Function

Lead Sponsor:

University of Oklahoma

Conditions:

Atrial Fibrillation

Heart Failure, Diastolic

Eligibility:

All Genders

21-90 years

Phase:

NA

Brief Summary

Low level transcutaneous vagus nerve stimulation (LLTS) involves delivery of electrical impulses transcutaneously at the auricular branch of vagus nerve and it has been shown to have anti-inflammatory...

Eligibility Criteria

Inclusion

  • Male and female patients older than 21 year old
  • Healthy volunteers free from diagnosis of AF, heart failure, coronary artery disease or diseases that affect the autonomic nervous system.
  • Patients with Paroxysmal Atrial Fibrillation
  • Patients with Heart Failure with Preserved Ejection Fraction (HFpEF)

Exclusion

  • Recent (\<6 months) stroke
  • Recent (\<6 months) myocardial infarction
  • Heart failure (NYHA class III or IV)
  • Left ventricular ejection fraction \<50%
  • Recurrent vaso-vagal syncopal episodes
  • Unilateral or bilateral vagotomy
  • Pregnancy or breast feeding
  • Uncontrolled diabetes or hypertension
  • Inability or unwillingness to understand and/or sign informed consent
  • Any serious disease that affects autonomic nervous system function
  • Any medications that affect autonomic nervous system function

Key Trial Info

Start Date :

November 30 2021

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

February 1 2025

Estimated Enrollment :

90 Patients enrolled

Trial Details

Trial ID

NCT04682704

Start Date

November 30 2021

End Date

February 1 2025

Last Update

February 21 2024

Active Locations (1)

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University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States, 73104