Status:
COMPLETED
Cardiac Markers in Depressed Patients With Coronary Heart Disease - R01HL147862
Lead Sponsor:
Washington University School of Medicine
Conditions:
Coronary Heart Disease
Depression
Eligibility:
All Genders
18+ years
Brief Summary
Depression doubles the risk of death in patients with coronary heart disease (CHD), but so far, there is insufficient evidence that we can reduce the risk of death by treating depression. This study w...
Detailed Description
Depression is associated with an increased risk of cardiac morbidity and mortality in coronary heart disease (CHD). Although safe and modestly effective treatments for major depression exist, only abo...
Eligibility Criteria
Inclusion
- Patients seen at the Washington University Medical Center with coronary heart disease (CHD) documented by coronary angiography or history of acute coronary syndrome (ACS).
- On a stable medication regimen (only minor changes in drug or dosage in last 30 days) are eligible for recruitment.
- Meet the diagnostic criteria for a depressive disorder, score ≥ 14 on the Beck Depression Inventory (BDI-II), and not meet any exclusion criteria.
Exclusion
- Thyroid disease or thyroid medications.
- Moderate to severe cognitive impairment.
- Major psychiatric comorbidities.
- Taking antidepressants other than a selective serotonin reuptake inhibitor (SSRI).
- Suicidal features.
- Current substance abuse.
- New York Heart Association (NYHA) class III or higher or a recent (\<3 months) acute coronary syndrome (ACS), coronary artery bypass graft surgery, cardiac hospitalization, or cardiac-related emergency department visit.
- Advanced malignancy, a disability that would prevent compliance with the study protocol, or physician or patient refusal.
Key Trial Info
Start Date :
December 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 31 2025
Estimated Enrollment :
175 Patients enrolled
Trial Details
Trial ID
NCT04682769
Start Date
December 1 2020
End Date
May 31 2025
Last Update
December 24 2025
Active Locations (1)
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1
Washington University
St Louis, Missouri, United States, 63108