Status:
COMPLETED
The Texture, Eating Rate and Glycaemic Index (TERAGI) Study
Lead Sponsor:
Singapore Institute of Food and Biotechnology Innovation
Conditions:
Adults
Eligibility:
MALE
21-40 years
Brief Summary
Rationale: It is now recognized that diet plays a critical role in the etiology and management of chronic diseases such as type-2 diabetes, obesity and cardiovascular diseases. Evidence shows an incre...
Detailed Description
Study Aims: The aim of this study is to understand how food texture and saliva characteristics influences oral processing behavior, bolus characteristics and postprandial glycaemic response. The stu...
Eligibility Criteria
Inclusion
- Male
- Chinese ethnicity
- Age between 21-40 years
- Weigh at least 45 kg
- Body mass index between 18to 25 kg/m²
- Normal blood pressure (\</=140/90 mmHg)
- Fasting blood glucose \<6.0 mmol/L
- Healthy dentition and ability to bite, chew and swallow normally
- No history of pain or discomfort in jaw movements or excessive teeth clenching or grinding, no caries or periodontal disease and no impaired salivation functions
Exclusion
- Partake in sports at the competitive and/or endurance levels
- Have known glucose-6-phosphate dehydrogenase (G6PD) deficiency
- Have known history of anaemia or thalassemia minor
- Have major chronic disease such as heart disease, cancer or diabetes mellitus
- Take insulin or drugs known to affect glucose metabolism
- Intentionally restrict food intake
- Have major medical or surgical event requiring hospitalization within the preceding 3 months
- Have taken antibiotics for 3 months before the study period
- Smoker
- Overnight shift worker
- Have any known food allergy (eg. anaphylaxis to peanuts)
- Have an active Tuberculosis (TB) condition or currently receiving treatment for TB
- Have any known Chronic Infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus(HCV), Human Immunodeficiency Virus (HIV)
- Member of the research team or their immediate family members. Immediate family member is defined as a spouse, parent, child, or sibling, whether biological or legally adopted
- Enrolled in a concurrent research study judged not to be scientifically or medically compatible with the study of the CNRC
- Have poor veins impeding venous access
- Have any history of severe vasovagal syncope (blackouts or near faints) following blood draws
Key Trial Info
Start Date :
May 2 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 15 2019
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04683432
Start Date
May 2 2019
End Date
July 15 2019
Last Update
December 24 2020
Active Locations (1)
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1
Singapore Institute of Food and Biotechnology Innovation (SIFBI)/Clinical Nutrition Research Centre
Singapore, Singapore, 117599