Status:
ACTIVE_NOT_RECRUITING
Compressed Intermittent Theta Burst Stimulation
Lead Sponsor:
University of Pennsylvania
Conditions:
Treatment Resistant Depression
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
In this proposal the investigators will use an accelerated TMS protocol that concentrates the magnetic stimulation that would usually occur over 6 weeks into 10 treatment sessions per days, for 5 cons...
Detailed Description
Major depressive disorder (MDD) is a disabling mental disorder with a lifetime prevalence of up to16% . Approximately 30% of MDD patients suffer treatment resistant depression (TRD), with at least 2 f...
Eligibility Criteria
Inclusion
- Gender, inclusive
- 18 - 70 years of age
- Meets Diagnostic and Statistical Manual of Mental Disorders criteria for primary diagnosis of MDD
- Patients must be fluent in English
- Participants must have the ability to provide consent
- Montgomery Asberg Depression Rating Scale score ≥20
- Failed 2+ prior treatments (treatment-refractory)
- May be on current anti-depressant medication at the discretion of PI, if not exceeding doses that would make TMS an increased risk
Exclusion
- Pregnancy (Female participants)
- MRI contraindication
- Medical condition that interferes with the collection or interpretation of MRI data
- Implanted devices such as: aneurysm clip or cardiac pacemaker
- Diagnosis of stroke, epilepsy, or other neurological disorders interfering with treatment at PI discretion
- Any factor the investigator believe may affect participant safety or compliance (ex: ≥100 miles from clinic)
- Current alcohol or substance use disorder in last 3 months
Key Trial Info
Start Date :
February 20 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 20 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04684706
Start Date
February 20 2020
End Date
December 20 2025
Last Update
July 16 2025
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Interventional Psychiatry, University of California San Diego
La Jolla, California, United States, 92093
2
Center for Neuromodulation in Depression and Stress
Philadelphia, Pennsylvania, United States, 19104