Status:
UNKNOWN
Exploring the Mechanisms and Dynamics of Clonal Evolution Leading to Recurrence in Prostate Cancer
Lead Sponsor:
Institute of Cancer Research, United Kingdom
Collaborating Sponsors:
Royal Marsden NHS Foundation Trust
Conditions:
Prostate Cancer Recurrent
Eligibility:
MALE
18+ years
Brief Summary
Prostate cancer is the most common cancer in males in the UK, and current estimates are that 1 in 8 will be diagnosed with prostate cancer in their lifetime. Although surgery or radiotherapy with horm...
Eligibility Criteria
Inclusion
- Male aged ≥18 years
- Prostate tumour biopsy specimens available at The Royal Marsden Hospital, Kingston Hospital, Epsom and St Helier Hospitals, St George's Hospital or Croydon University Hospital and \>2 primary tumour regions sampled
- Received primary radical radiotherapy and androgen deprivation therapy and remains under follow up at The Royal Marsden Hospital
- Willing and able to comply with blood sample collection
- Capable of understanding and complying with the protocol requirements and has given written, dated and signed informed consent AND
- Confirmed biochemical or radiological evidence of recurrent prostate cancer, and not yet received treatment for recurrent disease OR
- FORECAST patients with confirmed biochemical or radiological evidence of recurrent prostate cancer who have received or are currently receiving treatment but are progressing (rising PSA and/or evidence of progressive disease on imaging), or have a PSA \>2ng/ml
Exclusion
- 1\. Patients who have had another malignancy (excluding non-melanoma skin cancer, in-situ or superficial bladder cancer) treated within the previous 5 years
Key Trial Info
Start Date :
November 26 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2022
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04686188
Start Date
November 26 2020
End Date
September 1 2022
Last Update
December 28 2020
Active Locations (1)
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1
Royal Marsden Hospital
Sutton, Surrey, United Kingdom, SM2 5PT