Status:
UNKNOWN
Curcumin in Management of Chronic Obstructive Pulmonary Disease
Lead Sponsor:
Danbury Hospital
Conditions:
COPD
Eligibility:
All Genders
40-89 years
Phase:
NA
Brief Summary
In this double-blind, placebo-controlled trial, 120 patients with a diagnosis of COPD will be randomized to receive either a daily curcumin preparation or placebo for 90 days, in addition to the stand...
Detailed Description
Chronic obstructive pulmonary disease (COPD) kills more than 3 million people worldwide every year. COPD is managed mainly by pharmacological therapy during the stable stage. Research illustrates many...
Eligibility Criteria
Inclusion
- Provision of signed and dated informed consent form by the subject.
- Stated willingness to comply with all study procedures and availability for the duration of the study.
- Clinical diagnosis of COPD, defined as having a smoking history of at least 10 pack-years, a ratio of post bronchodilator forced expiratory volume in 1 second \[FEV1\] to forced vital capacity of \<70%, and a post bronchodilator FEV1 of \<80% of the predicted value.
- Patient has not had an acute exacerbation of COPD for at least 4 weeks of time of screening.
Exclusion
- Known allergic reactions to components of the study medication
- Use of turmeric as a spice or a dietary supplement within 3 months prior to enrollment
- Treatment with another investigational drug or other intervention at the time of enrollment
- Pregnancy or lactation
- Treatment with any chemotherapy agent, tacrolimus, talinolol, or sulfasalazine (due to the potential drug-drug interactions) at the time of enrolment
- Short-term steroid course received, for any reason, within 4 weeks prior to enrollment
- SGRQ-C is not available on the language preferred by the patient
- Patient is not able to undergo 6-minute walk due to a non-COPD related reason
Key Trial Info
Start Date :
January 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 15 2023
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04687449
Start Date
January 1 2022
End Date
December 15 2023
Last Update
July 9 2021
Active Locations (1)
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1
Pulmonary and Sleep Medicine clinic
Danbury, Connecticut, United States, 06810