Status:
UNKNOWN
Non-invasive Characterization of Systemic Microvascular Reactivity by Near-infrared Diffuse Optical Spectroscopy in COVID-19 Patients
Lead Sponsor:
Corporacion Parc Tauli
Collaborating Sponsors:
Institut de Ciències Fotòniques (ICFO)
Centre de Recerca Matemàtica
Conditions:
COVID-19
Endothelial Function
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to characterize microvascular reactivity on the forearm muscle using non-invasive near-infrared spectroscopy in critically ill COVID-19 patients, and to correlate its alte...
Detailed Description
After giving consent to participate in the study, the subjects included in the study will undergo a 15-minute measurement of tissue oxygen saturation (StO2) measured non-invasively on the forearm by m...
Eligibility Criteria
Inclusion
- Recent diagnosis of SARS-CoV2 infection
- Arterial hypoxemia and bilateral alveolar infiltrates, not explained by cardiac dysfunction or fluid overload.
Exclusion
- Severe peripheral vasculopathy
- Raynaud's syndrome
- Skin lesions or trauma in upper limbs interfering the placement of NIRS probe and/or the occlusion tourniquet
- Deep venous thrombosis in the upper limbs
Key Trial Info
Start Date :
May 25 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2022
Estimated Enrollment :
612 Patients enrolled
Trial Details
Trial ID
NCT04689477
Start Date
May 25 2020
End Date
October 1 2022
Last Update
August 1 2022
Active Locations (8)
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1
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
2
Hospital de Clinicas da UNICAMP
Campinas, São Paulo, Brazil
3
Hospital Das Clínicas University of Sao Paulo Medical School
São Paulo, Brazil
4
Hospital General de México
México, Mexico