Status:
COMPLETED
Biomarkers in Ocular Inflammation and Uveitis
Lead Sponsor:
National Eye Institute (NEI)
Conditions:
Uveitis
Ocular Inflammation
Eligibility:
All Genders
2+ years
Brief Summary
Background: Uveitis refers to a large group of inflammatory diseases in the eye. The inflammation can be caused by many factors, such as trauma, medicine, or infection. It can also be caused by syste...
Detailed Description
Study Description: Uveitis refers to a large group of intraocular inflammatory diseases that can cause devastating visual loss in adults and children. This is a retrospective study to identify factors...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- The study population will include subjects aged 4 or older and no upper limit for age will be set. All data will be derived only from subjects evaluated at the NEI eye clinic and enrolled in NEI protocols. This also applies to data from healthy volunteers.
- Subjects evaluated under the IRB protocols.
- AND
- Have a diagnosis of uveitis, ocular inflammation, scleritis or a disease known to be associated with intraocular inflammation, (e.g., sarcoidosis, Beh(SqrRoot)(Beta)et s disease, multiple sclerosis (MS) and lymphoma or COVID-19 or other infections)
- OR
- Serve as a control:
- unaffected control (healthy volunteer) or
- control with non-inflammatory related eye disease
- EXCLUSION CRITERIA:
- 1\. Patients without appropriate diagnostic and laboratory investigations for their diagnosis. Disease specific exclusion criteria will also be used. Patients will be excluded if appropriate laboratory investigations were not performed such as infectious serological tests and autoimmune labs. For posterior segment uveitis with retinal vasculitis, patients without fluorescein angiography will be excluded. Similarly, patients with choroiditis will be excluded if fundus autofluorescence studies were not performed. These disease specific exclusion criteria do not apply to healthy volunteers.
- Patients who were minors and NIH employees will be included in this retrospective study. The IRB approved protocols which these patients were managed under allow for the inclusion of these populations at time of original consent.
Exclusion
Key Trial Info
Start Date :
December 29 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 16 2022
Estimated Enrollment :
69 Patients enrolled
Trial Details
Trial ID
NCT04690829
Start Date
December 29 2020
End Date
November 16 2022
Last Update
September 19 2024
Active Locations (1)
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1
National Eye Institute (NEI)
Bethesda, Maryland, United States, 20892