Status:
UNKNOWN
EUS-guided PSE in Combination With EUS-guided Treatment of Varices for Patients With Portal Hypertension
Lead Sponsor:
Tongji Hospital
Conditions:
Gastroesophageal Varices
Hypersplenism
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
This study aims to evaluate the efficiency of EUS-guided combination therapy (EUS-guided PSE + EUS-guided treatment of varices) to EUS-guided treatment of varices alone in cirrhotic patients with port...
Detailed Description
Partial splenic embolization (PSE) was developed in the purpose of managing two common complications of portal hypertension including variceal bleeding and hypersplenism. The procedure is normally per...
Eligibility Criteria
Inclusion
- At the risk of gastroesophageal variceal hemorrhage; Acute gastroesophageal variceal hemorrhage; Hematemesis and/or melena resulted from gastroesophageal variceal hemorrhage of liver cirrhosis in the past.
- Hypersplenism is indicated by either abdominal ultrasound or CT image showing splenic enlargement or splenomegaly and CBC test showing deficiency of one or more blood cell lines.
- Consent form must be signed by patients or their guardians before entering the test.
Exclusion
- History of liver surgery or spleen surgery and liver cancer
- Coagulopathy (INR \> 1.5) or having been taken oral anticoagulation agents such as aspirin, warfarin, etc. in the past week.
- Existence of gastrointestinal endoscopic therapy contraindication; Hemorrhagic shock has not be corrected; Hepatic encephalopathy; Moderate to severe ascites, Poor liver function (Child - Pugh class C).
- Severe cardiorespiratory dysfunction, including sinus bradycardia, bronchial asthma, chronic obstructive pulmonary disease, heart failure, and atrioventricular block
- Pregnant women and nursing mothers.
- Absence of informed consent
Key Trial Info
Start Date :
January 5 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 5 2022
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT04692805
Start Date
January 5 2021
End Date
January 5 2022
Last Update
January 8 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The Division of Gastroenterology, Department of Internal Medicine at Tongji Hospital, , Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China, 430030