Status:
UNKNOWN
Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients
Lead Sponsor:
Pontificia Universidad Catolica de Chile
Collaborating Sponsors:
Fondo Nacional de Desarrollo Científico y Tecnológico, Chile
Conditions:
Septic Shock
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In septic shock patients, the hemodynamic coherence between systemic, regional and microcirculatory blood flow can be tracked by "capillary refill time (CRT) response to an increase in stroke volume i...
Detailed Description
INTRODUCTION Septic shock is associated with a high mortality risk of up to 30-60%. Multiple pathogenic factors can lead to progressive tissue hypoperfusion in the context of severe systemic inflammat...
Eligibility Criteria
Inclusion
- Septic shock according to the Sepsis-3 Consensus Conference \[1\], basically septic patients with hypotension requiring norepinephrine (NE) to maintain a MAP of 65 mmHg, and serum lactate levels \> 2 mmol/l after initial fluid resuscitation.
- Less than 24h after fulfilling criteria for septic shock
- Abnormal CRT (\>3 secs)
- Mechanical ventilation
- Sinus rhythm with positive predictors of fluid responsiveness \[4\]
- Continuous CO monitor, arterial line and central venous catheters in place
- Required fluid challenge as decided by the attending physician.
Exclusion
- Pregnancy
- Emergency surgery or dialytic procedure scheduled within the next two hours
- Do-not-resuscitate status
- Active bleeding
- Severe acute respiratory distress syndrome
- Right ventricular failure
Key Trial Info
Start Date :
February 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2023
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT04693923
Start Date
February 1 2021
End Date
September 1 2023
Last Update
January 5 2021
Active Locations (1)
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1
Pontificia Universidad Catolica de Chile
Santiago, Santiago Metropolitan, Chile, 7500000