Status:
COMPLETED
Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Normal Physiology
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
Background: Transcranial magnetic stimulation (TMS) of the brain has been used to change the activity and connections in the brain to improve memory. Researchers are interested in how these brain cha...
Detailed Description
Study Description: The Behavioral Neurology Unit studies the human brain systems underlying learning and adaptation with the goal of finding interventions to make these processes more efficient. In t...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- In order to be eligible to participate in this study, an individual must meet all of the following criteria:
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Ability of subject to understand and the willingness to sign a written informed consent document.
- Age 18-40 (inclusive)
- EXCLUSION CRITERIA
- An individual who meets any of the following criteria will be excluded from participation in this study:
- Any current major neurological or psychiatric disorder such as (but not limited to) stroke, Parkinson disease, Alzheimer disease, schizophrenia or major depression
- History of seizure
- Medications acting on the central nervous system, such as those that lowers the seizure threshold such as neuroleptics, beta lactams, isoniazid, metronidazole; benzodiazepines, tricyclic or other antidepressants; or prescription stimulants.
- Inability to provide informed consent
- Ferromagnetic metal in the cranial cavity or eye, implanted neural stimulator, cochlear implant, or ocular foreign body
- Implanted cardiac pacemaker or auto-defibrillator or pump
- Non-removable body piercing
- Claustrophobia
- Inability to lie supine for 1 hour
- Pregnancy, or plans to become pregnant during the study.
- Members of the NINDS BNU
- Subjects who have contraindications to MRI will follow the NMR Center guidelines for MR safety.
Exclusion
Key Trial Info
Start Date :
July 9 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 24 2023
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT04694131
Start Date
July 9 2021
End Date
February 24 2023
Last Update
July 4 2025
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892