Status:
RECRUITING
Survival of Monocytes Collected From Patients With Atrophic AMD in Retinal Pigmented Epithelium Explants
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Age Related Macular Degeneration
Eligibility:
All Genders
15+ years
Phase:
NA
Brief Summary
Age-related macular degeneration (AMD) affects 2 million people in France and is the main cause of irreversible blindness in France. All patients initially have an early form of the disease. This earl...
Eligibility Criteria
Inclusion
- General criteria:
- Male or female older than 50,
- Provide written informed consent,
- Patient affiliated to French social security,
- Maximum sampling volume (care + research) per 30-day period to be adapted according to the weight of the patient
- Specific criteria:
- Patient presenting in both eyes:
- Either the same type of AMD defined according to the modified international AREDS study (Ferris et al. 2013),
- or early AMD in one eye and atrophic AMD in the other eye, the patient will therefore be defined as being atrophic
- or early AMD in one eye and exudative AMD in the other eye, the patient will therefore be defined as exudative,
- or no retinal pathology (control group).
Exclusion
- General criteria:
- Patient whose weight is less than 50kg,
- Adult patient under guardianship or curatorship or unable to express consent,
- Person deprived of liberty,
- Patient participating in an ongoing clinical trial during the inclusion visit,
- Specific criteria:
- Patient with atrophic AMD in one eye and exudative AMD in the other eye,
- Patient presenting with chronic retinal pathologies other than AMD, defined according to the modified international AREDS study (Ferris et al. 2013) , in the included eye,
- Patient taking systemic drugs with an immunomodulatory action: immunosuppressants, immunomodulators, chemotherapy or corticosteroids,
- Patient with systemic pathologies modifying their immune status,
- Patient with a history of diabetes,
- Patient who had dynamic phototherapy on the included eye.
Key Trial Info
Start Date :
June 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 2 2025
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04697095
Start Date
June 1 2022
End Date
December 2 2025
Last Update
March 7 2025
Active Locations (2)
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1
Hôpital Edouard Herriot
Lyon, France, 69003
2
Service d'ophtalmologie-HOSPICES CIVILS DE LYON - Hôpital de la Croix-Rousse
Lyon, France, 69004