Status:
COMPLETED
Left Ventricular Diastolic Dysfunction as a Predictor of Weaning Failure From Mechanical Ventilation
Lead Sponsor:
Tanta University
Conditions:
Left Ventricular Diastolic Dysfunction
Weaning Failure
Eligibility:
All Genders
40-80 years
Brief Summary
Both premature and delayed extubation prolong the duration of mechanical ventilation and the intensive care unit (ICU) length of stay and increase morbidity and mortality. Therefore, accurate predicti...
Detailed Description
Weaning from mechanical ventilation is the process of gradual ventilatory support reduction to the patient subjected to mechanical ventilation for more than 24 hours. Determining the correct time to e...
Eligibility Criteria
Inclusion
- • Inclusion criteria: All patients aged more than 40 years who are intubated and mechanically ventilated for more than 48 hours, with improvement of underlying cause of acute respiratory failure and considered ready to undergo a spontaneous breathing trial (SBT) by the attending physician on the basis of readiness-to-wean criteria used in our surgical ICUn Criteria
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- Exclusion Criteria:
- Planning for tracheostomy after the SBT.
- Severe mitral stenosis, severe regurgitation, or prosthetic mitral valve.
- History of diaphragmatic dysfunction as diaphragmatic palsy, cervical spine injury, or neuromuscular disease.
- Pneumothorax or pneumo-mediastinum.
- Use of muscle-paralyzing agents within 48 h before the study.
- Poor echocardiographic windows or difficult windows of diaphragmatic movement as women in late pregnancy or obese patients.
- Extubation failure definitely caused by upper airway obstruction.
- Planned prophylactic noninvasive ventilation (NIV) after extubation.
- Atrial fibrillation or atrioventricular conduction abnormality.
- \-
Exclusion
Key Trial Info
Start Date :
August 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT04703387
Start Date
August 1 2020
End Date
December 31 2022
Last Update
February 27 2023
Active Locations (1)
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1
Tanta University
Tanta, Gharbia Governorate, Egypt, 31111