Status:
COMPLETED
Amniochorionic Membrane Cells in the Maternal Blood as a Biomarker for Preterm Birth
Lead Sponsor:
University of Aarhus
Collaborating Sponsors:
Arcedi Biotech
Aarhus University Hospital
Conditions:
Preterm Birth
Preterm Premature Rupture of Membrane
Eligibility:
FEMALE
18+ years
Brief Summary
Globally, preterm birth (15 mill. per year) is the leading cause of under-5 child mortality (1 mill. per year) and morbidity. Important pathways include preterm labor contractions, Preterm Prelabor Ru...
Detailed Description
Aim: The aim of the study is 1) to characterize circulating fetal amniochorionic membrane cells (ACM cells) in pregnant women and 2) to investigate if they can function as biomarkers of amniochorioni...
Eligibility Criteria
Inclusion
- Normal pregnancy at term (\> 37 weeks) the day before a planned caesarean section.
- Normal pregnancy at term (\> 37 weeks) with planned vaginal delivery.
- Women with preterm labor contractions \< 34 weeks admitted at the hospital.
- Women with PPROM \< 34 weeks admitted at the hospital.
- Normal pregnancy at gestational age 25+0 to 37.
- Normal pregnancy at gestational age 12 included at the nuchal translucency scan.
- Normal pregnancy at birth.
Exclusion
- Maternal age \< 18
- Women who does not understand the oral or written information
- Women who does not speak Danish
- Women who does not want to participate
- Women with complications in pregnancy
Key Trial Info
Start Date :
August 15 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 28 2024
Estimated Enrollment :
83 Patients enrolled
Trial Details
Trial ID
NCT04705935
Start Date
August 15 2022
End Date
June 28 2024
Last Update
December 18 2024
Active Locations (1)
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1
Aarhus University Hospital
Aarhus, Denmark, 8200