Status:
RECRUITING
Relationship of Airway Microbiota, Endotype and Phenotype in Adult Asthma
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Asthma
Eligibility:
All Genders
18+ years
Brief Summary
Increasing evidence supports that the respiratory microbiota, including viral and bacterial microorganisms, play important roles in respiratory health and disease. Microbial patterns in airways may in...
Detailed Description
This study plans to assess microbes in nasopharyngeal flock swab of asthma subjects. The swabs will be subjected to sequence analysis of 16S rRNA. Endotypes (e.g. TH1 vs TH2 inflammation) and phenotyp...
Eligibility Criteria
Inclusion
- Subjects aged between 18 and 80 years and have a diagnosis of asthma according to the Global Initiative for Asthma (GINA) document in 2020.
- Asthma is defined as those with a consistent history and prior documented evidence of variable airflow obstruction, with evidence of an increase in FEV1 greater than 12% or 200 mL following bronchodilator or bronchial hyperresponsiveness on bronchial provocation testing, when stable.
Exclusion
- Patients with respiratory diseases with other known respiratory diseases including chronic obstructive pulmonary disease, bronchiectasis, tuberculosis (TB)-destroyed lung parenchyma, history of lung resection and lung cancer
- Individuals older than 40 years with a smoking history of more than 10 pack-years or significant biomass exposure
- Patients currently randomized in other clinical studies
- Pregnant women
- Current smokers (who have not quit smoking in the past 1 year)
- Systemic and intranasal antibiotics treatment within 4 weeks
- Signs and symptoms of respiratory tract infections (upper or lower) within 4 weeks
Key Trial Info
Start Date :
June 22 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT04706988
Start Date
June 22 2021
End Date
December 31 2026
Last Update
March 21 2025
Active Locations (1)
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1
Prince of Wales Hospital
Shatin, Hong Kong