Status:
UNKNOWN
Oro-tracheal Intubation: Flurbiprofen Subglottic Instillation to Prevent Laryngeal Inflammation
Lead Sponsor:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions:
D010612
Eligibility:
All Genders
50-75 years
Phase:
PHASE2
Brief Summary
Most efficient system for airways controll during general anesthesia is oro-tracheal intubation, in order to allow mechanical ventilation and bronchial suction and to prevent gastric intake. However, ...
Detailed Description
Orotracheal intubation is the most efficient system for controlling the airways during general anesthesia, in order to keep them harmful, to prevent gastric intake and to allow mechanical ventilation ...
Eligibility Criteria
Inclusion
- Orotracheal intubation lasting 9-12 hours for elective interventions of myocardial revascularization or replacement/valve plastic in extracorporeal circulation and subsequent stay in intensive care.
- Ages of 50 and 75
- CLASS NYHA I or II
- Written consent to participation in the study and processing of their clinical data for the purpose of the study
Exclusion
- Previous upper air screw surgery
- Positive history for recent acute or chronic diseases of upper airways
- Tabagism
- Positive history for difficult intubation
- Orotracheal intubation with more than two attempts or with the help of devices
- Naso-tracheal intubation
- Positive history for gastro-esophageal reflux
- Patients who have or have been affected by peptic ulcer
- Patients with known hypersensitivity (bronchial asthma, urticaria, allergic phenomena) to flurbiprofen or any of the excipients, and to aspirin and other drugs belonging to the category of nonsteroidal anti-inflammatory drugs (NSAIDs)
- Pregnant and lactating women
- Patients participating in other experimental trials
- Patients who have not given written consent
- Any other clinical condition that the investigator says would make the patient unfit for study.
Key Trial Info
Start Date :
January 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 31 2022
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT04708964
Start Date
January 1 2021
End Date
January 31 2022
Last Update
January 14 2021
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