Status:
COMPLETED
Establishment of a Early Risk Model of ECMO in Children With ARDS
Lead Sponsor:
Children's Hospital of Fudan University
Collaborating Sponsors:
The Children's Hospital of Zhejiang University School of Medicine
Children's Hospital of Chongqing Medical University
Conditions:
ARDS
Eligibility:
All Genders
28-18 years
Brief Summary
The key problem in the treatment of ARDS is refractory hypoxemia. Extracorporeal Membrane Oxygenation (ECMO) is an extracorporeal oxygenation of venous blood to eliminate carbon dioxide and return to ...
Detailed Description
Severe acute respiratory distress syndrome (ARDS), especially those caused by severe viral pneumonia, is still an important factor in the death of children, with a case fatality rate of 55%. The treat...
Eligibility Criteria
Inclusion
- Acute onset; within 7 days of clinical insult
- Chest imaging (radiograph or computed tomography) findings of new infiltrates (unilateral or bilateral) consistent with acute parenchymal disease
- Edema not fully explained by fluid overload or cardiac failure
- May present as new acute lung disease in setting of chronic lung disease and/or heart disease
- OI≥16
- Viral etiology is clear
Exclusion
- Perinatal lung disease
- Large intracranial bleed with mass effect or need for neurosurgical intervention
- Hypoxic cardiac arrest without adequate CPR
- Irreversible underlying cardiac or lung pathology (and not a transplant candidate)
- Pulmonary hypertension and chronic lung disease
- Chronic multiorgan dysfunction
- Incurable malignancy
- Allogenic bone marrow recipients with pulmonary infiltrates
- Hepatic or renal failure
- Pertussis infection in infants
- Fungal pneumonia
- Immunodeficiency
Key Trial Info
Start Date :
January 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 30 2022
Estimated Enrollment :
95 Patients enrolled
Trial Details
Trial ID
NCT04710173
Start Date
January 1 2018
End Date
December 30 2022
Last Update
February 7 2024
Active Locations (3)
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1
Chinese PLA General Hospital
Beijing, China
2
Children's Hospital of Chongqing Medical University
Chongqing, China
3
Guangdong Provincial People's Hospital
Guanzhou, China