Status:
UNKNOWN
Characterization of Cytokines Expression During Enterovirus Meningitis in Paediatric Populations.
Lead Sponsor:
University Hospital, Clermont-Ferrand
Collaborating Sponsors:
Laboratory of virology, National Enterovirus and parechovirus Reference Center, University Hospital of Clermont-Ferrand
Conditions:
Meningitis Enterovirus
Eligibility:
All Genders
1-16 years
Brief Summary
Enteroviruses (EV) are the most frequent cause of acute meningitis in the paediatric population. Detection of enterovirus in cerebrospinal fluid (CSF) specimens by Polymerase Chain Reaction (PCR) is t...
Detailed Description
EVs are characterized by their high genetic variability, with more than 120 types described to date. They are involved in mild infections, such as febrile syndromes that may be associated with respira...
Eligibility Criteria
Inclusion
- Patients with proven enterovirus meningitis (RT- PCR EV positive)
- Control patients admitted for suspected meningitis infection but for whom the bacteriological (LCS culture/ blood culture negative) and virological diagnosis (testing for enteroviruses (RT-PCR negative) and parechoviruses (viruses responsible for symptoms similar to those of EVs) is negative
Exclusion
- For patients with EV meningitis, we will exclude:
- patients with co-infection
- haemorrhagic CSF samples
- samples (CSF or blood) for which we do not have access to EV viral load results
- samples (CSF or blood) for which we do not have access to the EV genotyping results
- For patients in the control group (without EV meningitis), we will exclude :
- Samples from patients with an infection (viral or bacterial) in the control group.
- haemorrhagic CSF samples
- CSF samples with pleocytosis (presence of CSF leucocytes).
- Blood samples with high CRP (CRP\>15mg/L).
Key Trial Info
Start Date :
April 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2021
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT04711876
Start Date
April 1 2021
End Date
June 1 2021
Last Update
January 15 2021
Active Locations (1)
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1
University Hospital, Clermont Ferrand
Clermont-Ferrand, AURA, France, 63000