Status:
UNKNOWN
Effect of Nalmefene on the Quality of Resuscitation in Patients Under General Anesthesia
Lead Sponsor:
RenJi Hospital
Collaborating Sponsors:
Shanghai Tong Ren Hospital
First Affiliated Hospital of Guangxi Medical University
Conditions:
Resuscitation
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
Postoperative recovery is an important part of the patient's experience. A good recovery period is an important guarantee for the recovery of postoperative organs and functions after surgery. However,...
Detailed Description
Postoperative recovery is an important part of the patient's experience, regardless of the type of surgery. The recovery and prognosis of postoperative anesthesia have gradually become important indic...
Eligibility Criteria
Inclusion
- Age is greater than or equal to 18 years old and less than 65 years old
- Patients who need tracheal intubation under general anesthesia at the right time for orthopedics, urology, and thoracic elective surgery
- Patients with American Society of Anesthesia physical status I or II
- BMI≥18kg/m2, and ≤30kg/m2
- The estimated anesthesia time is 1-4 hours.
- The intraoperative narcotic analgesics (Sufentanil and Remifentanil)
- The patient uses electronic intravenous analgesia pump after surgery
- The patient has informed consent
Exclusion
- patients who refused to participate in the study
- pantients who refuse intravenous analgesia
- medical history or family history of cognitive disorders,delirium, epilepsy, abalienation, anxiety or depression;
- recent use of anticholinergic drugs, antidepressants, antianxietics or anticonvulsants
- medical history of organic brain diseases or cranial vascular diseases
- patients with a history of allergy to any drug used in the study
- History of drug addiction and alcoholic intemperance or drug abuse
- The patient is diagnosed with severe heart and lung disease, or active heart disease, or severe hepatic dysfunction (ChildePugh class C), or severe renal dysfunction (undergoing dialysis before surgery) ,critical illness (preoperative ASA physical status classification \> =3)
- Participate in other clinical trials within 4 weeks
- Patients who, during surgery, presented complications （cerebrovascular accidents、heart failure、pneumothorax）or transfer to the intensive care unit during hospitalization, and patients who chose to abandon.
- Inability to communicate in the preoperative period because of coma, profound dementia, language barrier, or incapacity from severe disease
- Anesthesia time is \<1 hour or \>4 hours
- Patients had chronic pain (unsatisfied pain control for at least 1 month).
Key Trial Info
Start Date :
September 24 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2023
Estimated Enrollment :
520 Patients enrolled
Trial Details
Trial ID
NCT04713358
Start Date
September 24 2021
End Date
December 1 2023
Last Update
October 6 2022
Active Locations (4)
Enter a location and click search to find clinical trials sorted by distance.
1
The First Affiliated Hospital of Guangxi Medical University
Guangxi, Guangxi, China, 530000
2
Shanghai Tong Ren Hospital
Shanghai, Shanghai Municipality, China, 200000
3
Renji Hospital
Shanghai, Shanghai Municipality, China, 200127
4
The First Affiliated Hospital of Zhengzhou University
Henan, Zhengzhou, China, 450000