Status:
COMPLETED
Mesenchymal Stem Cells Therapy in Patients With COVID-19 Pneumonia
Lead Sponsor:
Kanuni Sultan Suleyman Training and Research Hospital
Conditions:
Coronavirus Disease 2019 (COVID-19) Pneumonia
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
Due to the cytokine storm that develops as a result of Coronavirus Disease 2019 (COVID-19) infection, some patients hospitalization to intensive care cause of pneumonia, Acute Respiratory Distress Syn...
Detailed Description
Study design and participants This study was a single-center open-label, randomized trial conducted at an Education and Training Hospital, Istanbul from May to July, 2020, and it was performed accordi...
Eligibility Criteria
Inclusion
- aged 18-90 male or female
- laboratory approve of RT-PCR (real-time reverse transcription polymerase chain reaction) with COVID-19 infection
- pneumonia assessed by chest radiography or computed tomography
- In accordance with any of the following: 1)Respiratory rate ≥ 30 times / min 2) oxygen saturation ≤ 93% 3) arterial pressure of oxygen/the fraction of inspired oxygen≤ 300mmHg, 4) pulmonary imaging of focus within 24-48 hours \> 50% progression
- patients who remain unresponsive to medications administered according to Ministry of health guidelines
- Patients who receiving invasive or non-invasive mechanical ventilation therapy in intensive care
Exclusion
- Pregnancy
- Any kind of cancer, severe liver disease
- Failure to provide informed consent or comply with test requirements
- Known allergy or hypersensitivity to MSCs
Key Trial Info
Start Date :
May 8 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 15 2020
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT04713878
Start Date
May 8 2020
End Date
July 15 2020
Last Update
January 20 2021
Active Locations (1)
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1
University of Health Sciences
Istanbul, Turkey (Türkiye)