Status:
RECRUITING
Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
Lead Sponsor:
University of Kansas Medical Center
Conditions:
Hypertension
Cardiovascular Diseases
Eligibility:
All Genders
35-65 years
Phase:
PHASE1
PHASE2
Brief Summary
The main purpose of research is to examine and understanding the development of hypertension in obese adults with insulin resistance. Findings from our studies will identify unique mechanisms that can...
Eligibility Criteria
Inclusion
- Obese: BMI \>30 m/kg2
- Middle-aged: 35-65 years
- Participants must be willing and able to discontinue taking any vitamin C or E supplements or omega-3 fatty acids beginning 2 weeks prior.
- Able and willing to provide written informed consent
Exclusion
- Diabetes mellitus: fasting glucose \< 1267 mg/dL and/or HbA1c \< 6.5%
- Currently taking a statin or antihypertension medication
- Hyperlipidemia: Fasting triglycerides \< 250 mg/dL
- Hypertension: \<130/80 mmHg
- History of heart disease (e.g., myocardial infarction, stent)
- History of vascular disease (e.g., bypass, stroke)
Key Trial Info
Start Date :
June 17 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2027
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT04715022
Start Date
June 17 2021
End Date
August 1 2027
Last Update
June 8 2025
Active Locations (1)
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1
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160