Status:
UNKNOWN
CT Perfusion Parameters Predict Vascular Pattern in Hepatocellular Carcinoma
Lead Sponsor:
Sun Yat-sen University
Conditions:
Hepatocellular Carcinoma
Eligibility:
All Genders
18-75 years
Brief Summary
Distinct vascular patterns (ECTC or Non-ECTC) of tumors plays an important role in tumor migration, metastasis and drug resistant in hepatocellular carcinoma (HCC). However, there is no non-invasive m...
Eligibility Criteria
Inclusion
- age over than 18 years old
- tumor size of less than 5 cm
- Child-Pugh A class liver function
- an Eastern Cooperative Oncology Group performance status of 0
- no previous treatment for HCC
- pathological diagnosis of hepatocellular carcinoma
- adequate organ function (white blood cell count ≥3.0 × 109/L, absolute neutrophil count ≥1.5 × 109/L, platelet count ≥75 × 109/L, aspartate transaminase and alanine transaminase≤5 × upper limit of the normal, creatinine clearance rate of ≤1.5 × upper limit of the normal, and left ventricular ejection ≥45%)
Exclusion
- Patients who received antitumor therapy before recurrence, including radiotherapy, transarterial chemoembolization, tyrosine kinase inhibitor, and immune checkpoint inhibitor
- a known medical history of HIV infection
- pregnancy or breastfeeding
- portal vein tumor thrombosis or hepatic vein thrombosis detected by any routine imaging modality, including ultrasonography, dynamic contrast CT and MRI
- any evidence of tumor metastasis or prior recurrence
- hepatic decompensation
Key Trial Info
Start Date :
February 15 2013
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2021
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04715321
Start Date
February 15 2013
End Date
December 31 2021
Last Update
December 29 2021
Active Locations (1)
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1
Cancer Center Sun Yat-sen University
Guangzhou, Guangdong, China, 510060