Status:
UNKNOWN
Physiology and Structure of the Small Airways in Patients With Chronic Airflow Obstruction or COVID-19
Lead Sponsor:
Imperial College London
Conditions:
Copd
COVID-19
Eligibility:
All Genders
16+ years
Brief Summary
The purpose of this research project is to study small airways physiological function in patients with chronic obstructive lung disease or COVID-19 and explore the relationship with in-vivo microanato...
Eligibility Criteria
Inclusion
- Age 16 or over
- Scheduled for bronchoscopy as part of clinical care or research protocol
- No bleeding diathesis or therapeutic anticoagulation
- COPD:
- FEV1/FVC ratio \<70% or
- Asthma:
- Diagnosed by standard clinical methods
- Post-bronchodilator FEV1 ≥60% predicted or COVID-19 infection or previous COVID-19 infection (confirmed as per local guidelines)
Exclusion
- Unable to provide informed consent
- Exacerbation of obstructive airways disease or respiratory infection requiring systemic antibiotics or corticosteroids in the 6 weeks prior to enrolment unless suffering from COVID-19 infection and bronchoscopy is required for clinical reasons
- Contra-indications to performing lung function testing
- Aortic aneurysm \>6cm
- Unstable cardiovascular disease (unstable angina, myocardial infarction or pulmonary embolism \<4 weeks prior)
- Severe aortic stenosis
- Pneumothorax
- Cerebral aneurysm
- Thoracic or abdominal surgery \<4 weeks prior
- Contra-indications to passing oesophageal balloons
- Oesophageal ulceration or varices
- Sinusitis, recent nasal surgery or epistaxis
Key Trial Info
Start Date :
August 23 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 2 2022
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT04716023
Start Date
August 23 2019
End Date
February 2 2022
Last Update
January 20 2021
Active Locations (1)
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1
The Royal Brompton
London, United Kingdom