Status:
UNKNOWN
Assesment of Retinal Nerve Fiber Layer in First Episode Depressive Patients Using Selective Serotonin Reuptake Inhibitor
Lead Sponsor:
Mehmet Diyaddin Güleken
Conditions:
Unipolar Depression
Eligibility:
All Genders
18-65 years
Brief Summary
The aim of this study is to assess the changes in retinal nerve fiber layer due to SSRI treatment in first-attack major depressive patients.
Detailed Description
Selective serotonin reuptake inhibitors (SSRIs) are among the most used and safe antidepressant drugs in the world. In previous studies, SSRIs have been found to cause an increase in brain gray matter...
Eligibility Criteria
Inclusion
- First attack depressive patients between 18 and 65 years
- Diagnosed with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders 5 / Clinical Version (SCID-5 / CV)
- Started to be treated with selective serotonin reuptake inhibitors
- Having a Standardized Mini Mental Test (SMMT) score of 24 or more and
- Healthy subjects with no psychiatric history, having a SCL-90-R (GSI) score of less than 1.0
Exclusion
- Depressive subjects with any neurological (cerebrovascular disease, head trauma, intracranial mass, dementia, epilepsy, multiple sclerosis, etc.) or general medical (such as diabetes, hypertension, myocardial infarction, etc.) diagnosis, with an ocular surgery or a history of ocular trauma, retinal pathology (detachment, etc.), other eye pathologies such as optic nerve neuropathy and refractive error, previous history of antidepressant drug use, alcohol-substance abuse or addiction,
- Healthy individuals with a history of psychiatric diagnosis or a SCL-90-R (GSI) score of 1.0 or above
Key Trial Info
Start Date :
September 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2021
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04717921
Start Date
September 1 2020
End Date
September 1 2021
Last Update
March 17 2021
Active Locations (1)
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1
Sağlık Bilimleri Üniversitesi Gazi Yaşargil Tranining and Research Hospital
Diyarbakır, Turkey (Türkiye), 21070