Status:
COMPLETED
Effect of Sildenafil Citrate on Mid Luteal Phase Uterine Artery Blood Flow in Patients With Recurrent Pregnancy Loss
Lead Sponsor:
Ain Shams University
Conditions:
Recurrent Pregnancy Loss
Eligibility:
FEMALE
18-35 years
Phase:
PHASE2
Brief Summary
Patients with recurrent pregnancy loss are known to have decreased uterine artery blood flow. Nitric oxide plays a major role in increasing uterine blood flow during the luteal phase. This study is do...
Detailed Description
Study Setting: The study will be conducted in recurrent pregnancy loss outpatient clinic at Ain shams university maternity hospital. Study Population: Patients with unexplained recurrent miscarriage ...
Eligibility Criteria
Inclusion
- History of 2 or more unexplained recurrent miscarriage.
- Child bearing period (18-35 years old).
- Non pregnant state.
- Regular menstrual cycles for the previous three months before the study.
- No hormonal contraception or intrauterine device.
- impaired uterine artery blood flow (PI \>2.02) (Mansour et al., 2018).
Exclusion
- 1-Having any possible causes of abortion: anatomical, genetic, endocrinological, infectious, or immunological.
- 2- Autoimmune disorders which may affect blood vessels and their blood flow (systemic lupus).
- 3- Systemic disease that might affect the hemodynamic indices (e.g. thrombocytopenia, thyrotoxicosis … etc.).
- 4- Diagnosed or treated thrombophilia. 5- Any vascular disease (e.g. coronary artery disease). 6- History of oophorectomy. 7- History of consanguinity. 8- Family history of chromosomal abnormalities (e.g. trisomy 21, trisomy 13… etc.).
Key Trial Info
Start Date :
September 5 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2019
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04718233
Start Date
September 5 2018
End Date
July 1 2019
Last Update
January 22 2021
Active Locations (1)
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1
Ain shams university maternity hospital
Cairo, Egypt, 25187