Status:
UNKNOWN
Comparison of Opioid and Duloxetine for Postoperative Pain Control After Total Knee Arthroplasty: RCT
Lead Sponsor:
The Catholic University of Korea
Conditions:
Total Knee Arthroplasty
Osteoarthritis, Knee
Eligibility:
All Genders
19+ years
Phase:
NA
Brief Summary
Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) has recently been reported to be effective in controlling pain in persistent chronic pain caused by joint surgery and arthritis. However, opioids are...
Detailed Description
For patients undergoing TKA for osteoarthritis of the knee joint, pain control will be performed using the same pain control technique (pain control using NSAID) until discharge (1 week after surgery)...
Eligibility Criteria
Inclusion
- Adults over age 19
- Patients undergoing total knee arthroplasty for osteoarthritis of the knee joint
- Patients with a pain VAS scale of 4 or more out of 10 after TKA with a pain in the knee joint during daily activities on flat ground
- Patients who are willing or able to follow doctor's instructions, including joint exercises
- Patients not participating in other clinical trials
- Patients who have received sufficient explanation for this clinical trial and agreed to participate
Exclusion
- Patients with secondary knee osteoarthritis
- Patients with hypersensitivity reactions and serious side effects to duloxetine or opioid
- Patients with inflammatory arthritis or crystalline arthritis
- Local infection to the lower extremities of the pain area, sepsis, or previous neurological abnormalities.
- Patients who underwent meniscus surgery on the knee joint in the painful area
- If there is construction or deformation of the knee joint in the pain area
- Patients with serious heart-related diseases such as cardiac arrest, a history of cerebral infarction, or ischemic heart disease
- Patients with high blood pressure with poor blood pressure control (Systolic Blood Pressure of\> 150 mmHg or Diastolic Blood Pressure\> 95 mmHg)
- Patients with abnormal liver function (ALT)\> 2.0 times the upper limit of normal (ULN) or blood urea nitrogen (BUN) or serum creatinine\> 2.0 times ULN)
Key Trial Info
Start Date :
January 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2022
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT04719585
Start Date
January 1 2021
End Date
December 1 2022
Last Update
January 22 2021
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