Status:
UNKNOWN
Effects of Lactobacillus Plantarum PS128 on the Parkinsonian Symptoms in Parkinson's Disease.
Lead Sponsor:
Professor Lu Neurological Clinic
Conditions:
Parkinson Disease
Eligibility:
All Genders
45-80 years
Phase:
NA
Brief Summary
This RCT study is designed to examine the extent to which L. plantarum PS128 can improve symptoms in PD patients. L. plantarum PS128 is a psychobiotic that regulates the level of dopamine in specific ...
Detailed Description
This RCT study is designed to examine the extent to which L. plantarum PS128 can improve symptoms in PD patients. L. plantarum PS128 is a psychobiotic that regulates the level of dopamine in specific ...
Eligibility Criteria
Inclusion
- Modified Hoehn \&Yahr stage, MHY 1-3
- 45-80 years old
- at least 9 years education
Exclusion
- Patients on antibiotics within the preceding one month
- Patients using of other probiotic products (sachet, capsule or tablet) within the preceding two weeks
- Have undergone surgery of liver, bladder, or gastrointestinal tract
- Have current or history of inflammatory bowel disease
- Have history of cancer
- Known allergy to probiotics
- Patients with comorbid dementia (Mini-Mental State Examination score ≤ 26) or major depression (The Beck Depression Inventory-II score ≥ 29)
- Have received deep brain stimulation
- Patients receiving artificial enteral or intravenous nutrition
- Diagnosed before 40 years old
- Poor control of other chronic diseases
- Not eligible judged by PI
Key Trial Info
Start Date :
July 6 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2023
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04722211
Start Date
July 6 2020
End Date
June 30 2023
Last Update
January 25 2021
Active Locations (1)
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1
Professor Lu Neurological Clinic
Taoyuan, Guishan Dist., Taiwan, 333