Status:
COMPLETED
Efficacy of Mouthwashes in Reducing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Viral Load in the Saliva
Lead Sponsor:
Queen Mary University of London
Collaborating Sponsors:
GlaxoSmithKline
Conditions:
Covid19
Coronavirus
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This is a single-blind, parallel-group, randomized pilot study designed to evaluate and compare the efficacy of 3 different mouthwashes containing 0.2% Chlorhexidine digluconate, 1.5% Hydroxide peroxi...
Eligibility Criteria
Inclusion
- All of the following criteria must be fulfilled for inclusion:
- Patients must have willingness to read and sign a copy of Informed Consent Form.
- Males and females, ≥ 18 years old.
- COVID-19 positive patients confirmed via any diagnostic test and/or presented with COVID-19 clinical symptoms at point of consent.
- Exclusion criteria for patients
- Patients presenting with any of the following will not be included in the trial:
- Known pre-existing chronic mucosal lesions e.g. lichen planus or other oropharyngeal lesions, reported by patient or recorded in the existing patient' medical notes;
- Patients currently intubated or not capable of mouth rinse or spit;
- History of head and neck radiotherapy or chemotherapy;
- Self-reported xerostomia;
- Known allergy or hypersensitivity to chlorhexidine digluconate or one of the mouthwashes constituents;
- Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or may interfere with the interpretation of trial results and, in the judgement of the investigator, would make the subject inappropriate for entry into this trial;
- Inability to comply with study protocol.
Exclusion
Key Trial Info
Start Date :
May 19 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 25 2021
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT04723446
Start Date
May 19 2021
End Date
October 25 2021
Last Update
September 14 2023
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Newham Hospital
London, United Kingdom
2
Royal London Hospital
London, United Kingdom