Status:
UNKNOWN
Meningitis Encephalitis: a Metagenomics-Based Etiology & Epidemiology Research
Lead Sponsor:
Beijing Tongren Hospital
Collaborating Sponsors:
Beijing Tiantan Hospital
Air Force Military Medical University, China
Conditions:
Central Nervous System Infections and Inflammations
Eligibility:
All Genders
14+ years
Brief Summary
Autoimmune encephalitis (AE) is caused by abnormal immune response mediated by autoimmune antibodies of patients, which can be detected by a serial of autoimmune antibodies\[4,5,6,7\]. At present, the...
Eligibility Criteria
Inclusion
- Either meet the items of 1, 2 or 1, 3
- The patient's age \>14 years old, acute or subacute onset (less than 3 months), (first onset, treatment with anti-infection drugs and/or immunotherapy ≤5 days);
- The patient has the following symptoms:
- Dysmnesia,
- Seizures,
- Mental disorders,
- Abnormal behavior,
- Unconsciousness or coma,
- Dyskinesia or involuntary movement,
- lalopathy or be reticent,
- Dysphagia, sleep disorders, or autonomic nervous dysfunction,
- Ataxia.
- Patients with meningeal irritation sign, intracranial hypertension and other manifestations, satisfy at least 3 of the following symptoms:
- Headache,
- Fever,
- Stiff neck,
- Disturbance of consciousness,
- Kernig sign or brudzinski sign was positive.
Exclusion
- 1\. Patients with suspected metabolic encephalopathy and toxic encephalopathy have the above manifestations,
- 2\. Patients with central nervous system tumor (primary or metastatic) have the above manifestations,
- 3\. The patient with non-organic mental illness,
- 4\. Patients who had undergone brain surgery within 6 months have the above symptoms after operation,
- 5\. Patients with traumatic brain injury have the above manifestations,
- 6\. Febrile convulsions caused by non-cerebral causes,
- 7\. Patients with above manifestations due to other reasons such as cerebrovascular disease, genetic disease, etc;
- 8\. Patients who refuse lumbar puncture or have contraindications to lumbar puncture;
- 9\. Patients who withdraw informed consent.
Key Trial Info
Start Date :
December 31 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2023
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT04724876
Start Date
December 31 2020
End Date
June 1 2023
Last Update
January 26 2021
Active Locations (1)
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1
Beijing Tongren Hospital,Capital Medical University
Beijing, Beijing Municipality, China, 100730