Status:
ACTIVE_NOT_RECRUITING
Spectacle Prescribing in Early Childhood
Lead Sponsor:
University of Arizona
Collaborating Sponsors:
National Eye Institute (NEI)
Conditions:
Astigmatism Bilateral
Eyeglasses
Eligibility:
All Genders
12-35 years
Phase:
NA
Brief Summary
The purpose of this study is to compare developmental outcome for young children (12 to 35 months of age) with astigmatism meeting American Academy of Ophthalmology spectacle prescribing guidelines an...
Detailed Description
The benefits and drawbacks of spectacle treatment for bilateral astigmatism in young children are not known. The SPEC study compares outcomes for young children (12 to \< 35 months of age) with astigm...
Eligibility Criteria
Inclusion
- Parent/guardian provision of signed and dated informed consent form for Baseline/Eligibility Examination.
- Completion of Baseline/Eligibility Examination with cycloplegia.
- Bilateral astigmatism: Astigmatism ≥2.25D in the most astigmatic eye and ≥1.75D in the fellow eye based on manual cycloplegic retinoscopy conducted at Baseline/Eligibility Examination.
- Parent/guardian willing to accept assignment to either randomized group.
- Parent/guardian provision of signed and dated informed consent form for randomized SPEC Study.
- Parent willing to commit to study visits every 180 days, to be contacted (phone, email, or text) for reports of spectacle wear, and to allow their child to wear the TheraMon® sensor on the spectacle headband.
- Child and Family are primarily English or Spanish speaking.
- Parent/guardian does not anticipate moving out of Tucson area prior to their child reaching age 1275 days (approximately age 3 ½ years).
- Parent/guardian has not enrolled another child in the SPEC trial.
Exclusion
- Gestational age \<32 weeks (per parent report).
- Anisometropia ≥1.50 D spherical equivalent per manual cycloplegic retinoscopy conducted at the Baseline/Eligibility Examination.
- Current manifest strabismus per Baseline/Eligibility Examination.
- Ocular pathology per Baseline/Eligibility Examination (H44\* or H25\* diagnosis code).
- Previously diagnosed manifest strabismus or other ocular abnormalities (per parent report and per medical record):
- H25\* (Cataract)
- H44\* (Disorders of the Globe)
- H50\* (Strabismus)
- H55\* (Irregular Eye Movement and Nystagmus)
- Q15.0 (Congenital Glaucoma)
- Other diagnosis of an ocular abnormality
- Previous spectacle wear, amblyopia therapy, or vision therapy (per parent report and per medical record).
- H53\* (Amblyopia)
- Other spectacle wear, amblyopia therapy, or vision therapy
- Current or previous diagnosis of developmental or neurological conditions (per parent report and per medical record):
- H90.5 Congenital Deafness, and related disorders of hearing loss.
- G40.909 Epilepsy or other seizure disorder.
- P07.34 Prematurity 31 weeks, and other prematurity less than 32 weeks.
- P91.6 Hypoxic Ischemic Encephalopathy
- Q90.9 Down Syndrome, and other congenital syndromes associated with developmental delay.
- Q04.4 Septo-Optic Dysplasia
- Q91-Q92 Trisomy Other (13, 18, partial, complete, unbalanced translocations, mosaicism, duplications)
- R62.50 Developmental Delay, and related disorders exhibiting a delay in one or more streams of development (e.g. language, fine motor, gross motor, social).
- Other diagnosis of a developmental or neurological condition
- History of allergic response to dilating eye drops (per parent report):
- Local redness and swelling of the eyelid consistent with contact dermatitis which resulted in the parent being informed that the child had a drug allergy to one of the dilating eye drops (proparacaine or cyclopentolate) or one of the carrier or preservative agents used in the formulation of these drops.
Key Trial Info
Start Date :
March 25 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2027
Estimated Enrollment :
88 Patients enrolled
Trial Details
Trial ID
NCT04728451
Start Date
March 25 2021
End Date
February 1 2027
Last Update
December 19 2024
Active Locations (1)
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1
The University of Arizona
Tucson, Arizona, United States, 85719