Status:
UNKNOWN
Assessment of Cardiac Function Using Combined Cardiovascular Magnetic Resonance and Cardiopulmonary Exercise Testing (CMR-CPET)
Lead Sponsor:
Royal Free Hospital NHS Foundation Trust
Collaborating Sponsors:
Actelion
British Heart Foundation
Conditions:
Pulmonary Hypertension
Eligibility:
All Genders
18-80 years
Brief Summary
What problems limit patients' response to exercise? Using exercise cardiac magnetic resonance imaging to assess the heart's response, with simultaneous measurement of respiratory oxygen and carbon dio...
Detailed Description
Background and study aims Many medical conditions that affect the heart and lungs can cause breathlessness. People affected by breathlessness often require a number of tests to diagnose the medical co...
Eligibility Criteria
Inclusion
- Age 18-80 years
- Symptoms of breathlessness on exertion under the care of cardiology, pulmonary hypertension or rheumatology clinics for non-ischaemic cardiovascular disease
- Willing and able to provide written informed consent
Exclusion
- Previous ischaemic heart disease (including angina, myocardial infarction, PCI, CABG)
- Unstable symptoms (including crescendo angina or angina at rest, and syncope on exercise)\*
- Arrhythmia\*\*
- Musculoskeletal disease preventing exercise
- Patients unable to provide consent
- General contraindications to CMR (e.g. implanted metal objects, pregnancy, severe claustrophobia)
- Significant parenchymal lung disease (defined as \>20% extent parenchymal disease on CT)
- WHO functional class IV symptoms \*Patients with unstable symptoms have been excluded as it would be unsafe for them to perform exercise whilst in a MRI scanner. Patients unable to exercise, WHO functional class IV and those with significant lung disease have been excluded as they would be unable to complete the exercise protocol \*\*The researchers have excluded patients with arrhythmia as this can reduce the reliability of some of the CMR image sequences and also results in less predictable heart rate response to exercise
Key Trial Info
Start Date :
March 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2021
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04729777
Start Date
March 1 2019
End Date
October 1 2021
Last Update
January 28 2021
Active Locations (1)
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1
Royal Free Hospital NHS Foundation Trust
London, United Kingdom, NW3 2QG