Status:
COMPLETED
Comparative Analgesic Effects of Paracetamol/Codeine and Ibuprofen on Pain After Third Molar Surgery
Lead Sponsor:
University of Roma La Sapienza
Conditions:
To Control Pain After Third Molar Surgery
Eligibility:
All Genders
15-29 years
Phase:
PHASE4
Brief Summary
To compare analgesic effects of preoperative administration of paracetamol 500 milligram plus codeine 30 milligram in single-tablet and effervescent formulation to ibuprofen 400 milligram, and placebo...
Detailed Description
Materials and methods: One hundred twenty healthy outpatients aged 15 to 29 years undergoing surgical removal of one bony impacted mandibular third molar were enrolled in this, single-center, prospect...
Eligibility Criteria
Inclusion
- healthy status (ASA class I);
- nonsmoker;
- not pregnant or breastfeeding;
- no medication consumption in the past 21 days;
- good oral hygiene;
- bony impaction of one mandibular third molars;
- the presence of the first and second molars;
- compliance to cooperate with the research protocol.
Exclusion
- chronic systemic disease;
- medications with potential interaction to paracetamol-codeine or ibuprofen;
- a history of intolerance or hypersensitivity to the study drugs;
- any pre-existing pain and acute inflammatory or infectious conditions; - inability to understand or perform the study procedure.
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 14 2020
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04730297
Start Date
January 1 2018
End Date
October 14 2020
Last Update
January 29 2021
Active Locations (1)
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1
Maria Paola Cristalli
Roma, Italy, 00100