Status:
COMPLETED
Reducing Obesity and Cartilage Compression in Knees
Lead Sponsor:
Duke University
Conditions:
Obesity
Osteoarthritis
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
OA is a degenerative joint disease that involves the degradation of articular cartilage and underlying subchondral bone. Obesity is identified as a critical and potentially modifiable risk factor for ...
Detailed Description
Appropriate study power will be achieved with 35 participants in the weight loss group and 35 participants in the weight maintenance control group (see Data Analysis and Statistical Considerations). W...
Eligibility Criteria
Inclusion
- BMI (BMI ≥29 - \<40)
- Age between 18 - 45
Exclusion
- History of lower extremity injury
- Evidence of symptoms of knee OA
- Knee misalignment
- Evidence of pregnancy
- Thigh unable to fit in MRI coil
- Body waist fit in MRI
- Have no metals in the body
Key Trial Info
Start Date :
June 5 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 17 2024
Estimated Enrollment :
88 Patients enrolled
Trial Details
Trial ID
NCT04730557
Start Date
June 5 2020
End Date
May 17 2024
Last Update
June 6 2024
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27710