Status:
UNKNOWN
Cannabidiol Treatment for Severe and Critical Coronavirus (COVID-19) Pulmonary Infection
Lead Sponsor:
Rabin Medical Center
Conditions:
COVID-19
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
Current management of COVID-19 (coronavirus) is mainly supportive, and respiratory failure from acute respiratory distress syndrome (ARDS) is the leading cause of mortality. Cytokines and chemokines a...
Detailed Description
Study objectives: 1. Describe the impact of CBD on the cytokine profile in patients with severe and critical COVID-19 infection. 2. Explore the safety and efficacy of CBD treatment in patients with s...
Eligibility Criteria
Inclusion
- Laboratory-confirmed novel COVID-19 infection as determined by polymerase chain reaction, or other commercial or public health assay in oropharyngeal specimen within 72 hours prior to hospitalization.
- Patients with severe disease defined as individuals with pneumonia and one or more of the following criteria:
- Respiratory rate ≥ 30/min.
- Oxygen saturation at room air less than 93%.
- Patients with critical disease defined as individuals with respiratory failure requiring mechanical ventilation
- Age18 years and older
- Informed consent has to be obtained from all patients. The patient will sign the Informed Consent Form before entering the study.
- Some patients are expected to be unable to legally consent due to critical illness, and sedation. In case a legal guardian exists, approach for consent will be made.
Exclusion
- Allergy to CBD
- Documented infection
- Pregnant and lactating women
- Predicted clinically that there is no hope of survival
- GI intolerance
Key Trial Info
Start Date :
January 10 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 30 2022
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04731116
Start Date
January 10 2021
End Date
April 30 2022
Last Update
January 29 2021
Active Locations (1)
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1
Rabin Medical Center
Petah Tikva, Israel