Status:
NOT_YET_RECRUITING
Physiologic Change of Posterior Ocular Segment During Pregnancy
Lead Sponsor:
Khon Kaen University
Conditions:
Retinal Vascular
Eligibility:
FEMALE
18+ years
Phase:
NA
Brief Summary
Women's physiology changes markedly during normal pregnancy. The most distinct alterations occur in the hormonal and cardiovascular systems. There is a dramatic increase in both estrogen and progester...
Detailed Description
Ocular anterior segment changes during pregnancy are the followings * Melanogenesis of eyelid and facial skin -\> melasma * Cellular alteration of lacrimal and meibomian gland -\> dry eye symptoms * ...
Eligibility Criteria
Inclusion
- Healthy pregnant women
- Age \> 18 years
- Gestational age \< 12 weeks
- Written informed consent
Exclusion
- High risk pregnancy such as multifetal pregnancy and preeclampsia
- History of vitreoretinal diseases such as retinal vasculitis
- History of intraocular laser treatments or intraocular surgeries
- History of systemic diseases such as diabetes mellitus and thyroid disease
- Refractive error; spherical equivalence \> 4 diopters
- Clear ocular media
- Could not be taken the images by non-dilated pupil
- Withdrawal Criteria:
- Preterm labor; gestational age \< 34 weeks
- Multifetal pregnancy was demonstrated by ultrasound
- Severe labor and delivery complications such as
- Severe postpartum complications such as postpartum bleeding
- Taking hormone during the follow-up period
Key Trial Info
Start Date :
July 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
69 Patients enrolled
Trial Details
Trial ID
NCT04731415
Start Date
July 1 2021
End Date
June 30 2026
Last Update
June 30 2021
Active Locations (1)
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1
Khon Kaen University
Khon Kaen, Thailand, 40002