Status:
UNKNOWN
NLR and PRL in Neurocognitive Disorders
Lead Sponsor:
University of Thessaly
Collaborating Sponsors:
University Hospital, Ioannina
Larissa University Hospital
Conditions:
Neurocognitive Disorders
Neutrophil-Lymphocyte Ratio
Eligibility:
All Genders
45-80 years
Brief Summary
Preliminary evidence suggest a possible relationship between Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR) and perioperative neurocognitive disorders (NCD). We are going to inv...
Detailed Description
It is estimated that approximately 10% of elderly undergoing surgery will develop cognitive changes perioperatively, while in some reports the incidence rises up to 80%. Despite the reported high prev...
Eligibility Criteria
Inclusion
- 45 - 80 years
- American Society of Anesthesiologists physical status I to III
- elective general, urological, gynecological and orthopedic surgery under general anesthesia
- native speakers of the Greek language
Exclusion
- refused to participate or sign the informed consent form
- had undergone surgery or anesthesia within the last 30 days
- had any prior or current history involving an affliction of the central nervous system
- were diagnosed with severe cognitive decline based on the 16 - item Informant Questionnaire on Cognitive Decline (IQCODE - 16)
- suffered from severe hearing or visual impairment
- any psychiatric disorder
- had a score \>5 in the Geriatric Depression Scale (GDS - 15)
- or a score in females \< 4 males \< 2 in the Lawton - Brody Instrumental Activities of Daily Living Scale (I.A.D.L.)
- reported alcohol consumption \> 35 units/week
- drug dependence
- had undergone previous neuropsychological testing
- Diabetes Mellitus type II with \> 10 years of diagnosis
- Diabetes Mellitus type I
- Hemoglobin A1c (HbA1c) \> 7.5%
- suffered from hemodynamical instability (\> 20% alterations of blood pressure perioperatively)
- or desaturation (one or more events of SpO2 \< 80% for more than 2 minutes) peri-operatively
- or blood loss of more than one unit
Key Trial Info
Start Date :
December 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2021
Estimated Enrollment :
288 Patients enrolled
Trial Details
Trial ID
NCT04736290
Start Date
December 1 2015
End Date
December 30 2021
Last Update
April 28 2021
Active Locations (1)
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1
University of Thessaly
Larissa, Greece, 41335