Status:
COMPLETED
Prognostic Biomarkers in Predicting Mortality in Respiratory Patients With Ventilator-Associated Pneumonia
Lead Sponsor:
Assiut University
Conditions:
Ventilator Associated Pneumonia
Eligibility:
All Genders
18+ years
Brief Summary
The aim of this study is to evaluate prognostic efficiency RDW and NLR for mortality prediction in respiratory patients with VAP.
Detailed Description
Ventilator-associated pneumonia (VAP) is the most common nosocomial infection. VAP continues to be a leading cause of morbidity and mortality in the nosocomial setting. Red cell distribution width (RD...
Eligibility Criteria
Inclusion
- Respiratory failure needs mechanical ventilator support \> 48 hrs. VAP was defined as an acute lower respiratory tract infection in mechanically ventilated patient \> 48 hrs with a new or progressing infiltrate on chest radiograph and who met at least two of the following clinical criteria: body temperature \>38°C or \<36°C with no other recognized cause, white blood cell count \>10,000 /mm3 or \<5000 /mm3, or a macroscopically purulent tracheal aspirate
- Only the first VAP episode was included
Exclusion
- Neutropenia (\< 500 cells/ml) before the development of VAP.
- Conditions are known to influence total and differential WBC counts such as chronic inflammatory conditions, hematologic disorders, history of chemotherapy, or radiotherapy within 4 weeks before enrollment.
- Conditions are known to affect RDW as anemia due to nutritional deficiency (ie, iron, vitamin B12, and folic acid).
- Patients with HIV/AIDS
Key Trial Info
Start Date :
April 6 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 7 2019
Estimated Enrollment :
136 Patients enrolled
Trial Details
Trial ID
NCT04739748
Start Date
April 6 2018
End Date
December 7 2019
Last Update
February 8 2021
Active Locations (1)
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1
Chest Department-faculty of medicine-Assuit university
Asyut, Egypt