Status:
WITHDRAWN
Research on Translational Outcomes of Alcohol (Project RETRO)
Lead Sponsor:
University of Washington
Conditions:
Alcohol Drinking
Eligibility:
All Genders
21-24 years
Phase:
PHASE4
Brief Summary
The primary aim of the current study is to assess the effect of a single dose of carbidopa-levodopa on ad libitum alcohol consumption and alcohol craving in young adults with a history of binge drinki...
Detailed Description
This is a small (N = 42) 2-arm, double-blind, randomized controlled pilot study to assess the effect of a single dose of immediate release carbidopa-levodopa (50mg/500mg) to acutely reduce alcohol con...
Eligibility Criteria
Inclusion
- Enrolled in 2- or 4-year college program
- Currently living in the Seattle Metropolitan area
- Have at least two or more episodes of heavy episodic drinking (4/5 or more drinks in a 2 hours for women/men) in the past 30 days.
Exclusion
- Exclusion criteria include:
- past-month severe alcohol or other substance use disorders,
- mood or anxiety disorder
- suicidal ideation
- risk of psychotic disorders
- excessive alcohol use reaching a Blood Alcohol Level greater than .30%
- history of serious medical conditions, regular use of prescription psychotropic or pain medication
- history of negative reactions to alcohol
- history of treatment for alcohol use disorder
- pregnancy or nursing.
- use of non-selective monoamine oxidase inhibitors in the past 2 weeks.
- narrow-angle glaucoma
- undiagnosed skin lesions,
- have a history of melanoma, cardiac issues or peptic ulcer.
- Currently taking or prescribed any form of levodopa or D2 agonists, D2 antagonists, isoniazid, methylphenidate, bupropion, Viagra, or phosphodiesterase inhibitors.
Key Trial Info
Start Date :
February 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2023
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04742348
Start Date
February 1 2023
End Date
August 1 2023
Last Update
February 13 2023
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