Status:
RECRUITING
Neural Bases of Vocal Sensorimotor Impairment in Aphasia
Lead Sponsor:
The University of Texas at Dallas
Collaborating Sponsors:
National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions:
Aphasia
Eligibility:
All Genders
21-75 years
Phase:
NA
Brief Summary
Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control. While recovery can be promoted with speech therapy, imp...
Eligibility Criteria
Inclusion
- A total of 50 individuals with aphasia due to chronic left hemisphere stroke (\> 6 months post-stroke) and 50 age- and gender-matched healthy control subjects will be recruited in this study. The general inclusion criteria for all subjects include: age range 21-75 years, right-handed, and native speaker of English. The aphasic subjects have previously undergone neuro-psychological speech/language testing and have been diagnosed with one type of aphasia (e.g., Broca's, Wernicke's, conduction or anomic). Subjects in the control group will meet the inclusion criteria with having normal voice, speech, language, and hearing function and no history of neurological and psychiatric disorder. We expect that a significant proportion of aphasic patients will show symptoms associated with Apraxia of Speech (AOS) or dysarthria; however, these patients will not be excluded unless their deficits will preclude them from performing the experimental tasks.
Exclusion
- Subjects with moderate to severe hearing, memory, and/or cognitive impairments will be excluded for both groups. In addition, subjects with history of peripheral laryngeal disorders (e.g., paresis or vocal fold paralysis) will be excluded. Subjects will undergo safety screening and will be excluded if there are any factors counter-indicative for EEG and/or MRI scanning.
Key Trial Info
Start Date :
July 11 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 28 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04742894
Start Date
July 11 2021
End Date
February 28 2026
Last Update
June 10 2025
Active Locations (3)
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1
University of California Irvine
Irvine, California, United States, 92697
2
University of South Carolina
Columbia, South Carolina, United States, 29208
3
The University of Texas at Dallas
Richardson, Texas, United States, 75080