Status:
UNKNOWN
Effects of Small-dose S-ketamine on Anesthesia-induced Atelectasis in Anesthetized Patients Accessed by Pulmonary Ultrasound
Lead Sponsor:
Beijing Tiantan Hospital
Conditions:
Atelectasis
Eligibility:
All Genders
18-60 years
Phase:
EARLY_PHASE1
Brief Summary
Background: Atelectasis occurs in the majority of patients with general anesthesia, which can lead to postoperative pulmonary complications (PPCs) and affect the postoperative outcome. However, there ...
Eligibility Criteria
Inclusion
- Age of 18 - 60 years;
- American Society of Anesthesiologists (ASA) physical status of I - II;
- Patients scheduled for urinary, obstetrics and gynecology surgery in supine position or lithotomy position under general anesthesia, and the expected operation time is more than 1 hour;
- Patients and their authorized surrogates have signed the informed consent form.
Exclusion
- Patients who have difficulty in applying pulmonary ultrasound, such as chest fractures, surgical history, etc;
- Patients who have a history of upper respiratory tract infection one month before surgery, or a history of smoking more than 6 packs/year;
- Preoperative chest X-ray or CT abnormalities, including atelectasis, pneumothorax, pleural effusion or pneumonia;
- BMI\>30kg/㎡;
- Expected difficulty in intubation or mask ventilation;
- Patients with significant increase in intraocular pressure and intracranial pressure before surgery;
- Patients allergic to S-ketamine, propofol and opioids.
- Patients with a positive history of psychiatric disorders.
Key Trial Info
Start Date :
March 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2022
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04745286
Start Date
March 1 2021
End Date
March 1 2022
Last Update
February 9 2021
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