Status:
RECRUITING
Identification of Circulating microRNAs in Adolescent Idiopathic Scoliosis
Lead Sponsor:
Istituto Ortopedico Rizzoli
Conditions:
Adolescent Idiopathic Scoliosis
Eligibility:
All Genders
11-17 years
Brief Summary
The aim of the present study is to evaluate the expression of a large panel of microRNAs, already known and validated in other ortopedic pathologies and bone metabolism, in the plasma of Adolescent Id...
Detailed Description
MATERIALS AND METHODS: 1) Collection of a venous blood sample from patients enrolled with AIS or controls, and subsequent separation of plasma; 2) Isolation of circulating total RNA from the plasma of...
Eligibility Criteria
Inclusion
- Cases:
- Age between 11-17 years
- Diagnosis of idiopathic scoliosis with a Cobb angle\> 10 °
- Minimum follow-up of two years
- Clinical data and radiological tests available and no surgical treatment prior to enrollment in the study
- Controls:
- Age between 11-17 years
- Healthy subjects not affected by orthopedic and oncological diseases
Exclusion
- Severe cognitive impairment or psychiatric disorders
- Patients with scoliosis due to secondary causes
- Women of childbearing age must not be pregnant
Key Trial Info
Start Date :
July 22 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 21 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04746586
Start Date
July 22 2020
End Date
December 21 2025
Last Update
January 27 2025
Active Locations (1)
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1
Dipartimento Rizzoli-Sicilia
Bagheria, Italy, 90011