Status:
WITHDRAWN
In-depth Investigation of Brain Network Interactions
Lead Sponsor:
Northwestern University
Conditions:
Episodic Memory
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Brain stimulation is a means to potentially remediate symptoms in a range of neurological and psychiatric diseases, however, precise targeting of stimulation is necessary to ensure efficacy. The propo...
Detailed Description
Research Statement SIGNIFICANCE Memory impairments are common to several neurological and psychiatric disorders, including Alzheimer's disease and depression, and these impose a heavy burden on patien...
Eligibility Criteria
Inclusion
- Participants will be inpatients of the Northwestern Memorial Hospital Comprehensive Epilepsy Center undergoing intracranial electroencephalography for presurgical planning as part of their routine care for epilepsy. Participants will be recruited to participate in the study if their epilepsy monitoring procedures will include placement of recording electrodes at locations of interest to our study, which include the medial temporal lobe, frontal cortex, parietal cortex, and temporal cortex. The decision regarding where to place electrodes is made for purely clinical purposes and we recruit patients with locations that are relevant to our research question as a convenience sample.
- We will exclude children under the age of 18 years as brain development is still occurring in children under the age of 18 years relative to adults. Furthermore, children rarely receive iEEG for epilepsy and therefore would not be available to recruit into the study. Special populations listed below will not participate in this study. Excluded populations include:
- Adults legally unable to provide informed consent
- Individuals who are not yet adults (children below the age of 18)
- Pregnant women
- Prisoners To help determine eligibility for the MRI portion of the study, a safety questionnaire will be administered by research staff prior to receiving an MRI. Answers to these questions are used to determine whether subjects meet any of the exclusionary criteria listed next. Exclusions for MRI include standard MRI contraindications, including claustrophobia, metal implants or fragments in the body, and actual or potential pregnancy.
Exclusion
Key Trial Info
Start Date :
August 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2027
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04748146
Start Date
August 1 2026
End Date
August 1 2027
Last Update
July 25 2025
Active Locations (1)
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1
Northwestern Memorial Hospital
Chicago, Illinois, United States, 60611