Status:
UNKNOWN
Home-based Exercise Therapy for Patients With PAD
Lead Sponsor:
Centro Hospitalar do Porto
Collaborating Sponsors:
Foundation for Science and Technology, Portugal
University of Trás-os-Montes and Alto Douro
Conditions:
Peripheral Arterial Disease (PAD)
Intermittent Claudication
Eligibility:
All Genders
50-80 years
Phase:
NA
Brief Summary
Cardiovascular disease represents a considerable economic burden to society and effective preventive measures are necessary. Patients with peripheral arterial disease (PAD) have a severe impairment of...
Detailed Description
Exercise training has been incorporated into current guidelines for the management of PAD. Multiple societal guidelines, including the American Heart Association Task Force on Clinical Practice Guidel...
Eligibility Criteria
Inclusion
- PAD with IC (Fontaine II ou Rutherford 1-3) due to atherosclerotic disease;
- ABI below 0.9 at rest or below 0.73 after exercise (20% decrease);
- Age range between 50 and 80;
- MWD in treadmill test between 50 and 500 meters;
Exclusion
- Asymptomatic PAD;
- Critical Ischemia (Fontaine III/IV or Rutherford 4-6);
- Previous lower extremity vascular surgery, angioplasty, or lumbar sympathectomy;
- Any condition other than PAD that limits walking;
- Miocardial Infarction or Unstable Angina in the last 6 months;
- Inability to obtain ABI measure because of non-compressible vessels;
- Use of cilostazol and pentoxifylline initiated within 3 months before the investigation;
- Active cancer, renal disease, or liver disease;
- Severe chronic obstructive pulmonary disease (GOLD stage III/IV);
- Severe congestive heart failure (NYHA class III/IV);
Key Trial Info
Start Date :
February 9 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 30 2023
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04749732
Start Date
February 9 2021
End Date
November 30 2023
Last Update
February 10 2023
Active Locations (1)
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1
Centro Hospitalar do Porto
Porto, Portugal, 4099-001