Status:
COMPLETED
Long-term Effect of θ Burst Magnetic Stimulation on Clinical Symptoms of Alzheimer Disease
Lead Sponsor:
Anhui Medical University
Conditions:
Repetitive Transcranial Magnetic Stimulation
Eligibility:
All Genders
50-80 years
Phase:
NA
Brief Summary
This was a randomized, single-blind, parallel, placebo-controlled clinical trial assessing the efficacy of neuronavigational TBS among patients with AD. Fourty late-onset AD were included in the study...
Eligibility Criteria
Inclusion
- Subject diagnosed with early Alzheimer's disease or related diseases according to NINCDS-ACDRADA criteria.
- Subjects must have a MMSE score between 10 and 27,indicating mild cognitive impairment or dementia
- CDR score ≤ 2
- Subject under treatment by IAChE for at least 3 Weeks.
- psychotropic treatments are tolerated if they were administered and unchanged for at least 3 months
Exclusion
- CDR \> 2
- Any history or clinical signs of other severe psychiatric illnesses (like major depression,psychosis or obsessive compulsive disorder).
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- History of head injury,stroke,or other neurologic disease.
- Organic brain defects on T1 or T2 images.
- History of seizures or unexplained loss of consciousness.
- Implanted pacemaker,medication pump,vagal stimulator,deep brain stimulator.
- Family history of medication refractory epilepsy.
- History of substance abuse within the last 6 months.
Key Trial Info
Start Date :
April 21 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT04754152
Start Date
April 21 2021
End Date
December 31 2022
Last Update
February 28 2023
Active Locations (1)
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1
Cognitive Neuropsychology Lab Anhui Medical University
Hefei, Anhui, China, 230022