Status:
COMPLETED
Paediatric Inflammatory Multisystem Syndrome During COVID-19 Pandemic
Lead Sponsor:
Anglia Ruskin University
Conditions:
Paediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-Cov-2
Eligibility:
All Genders
3-16 years
Brief Summary
During the COVID-19 pandemic, a small minority of children have been presenting to acute paediatric services with a new syndrome, Paediatric Inflammatory Multisystem Syndrome temporally associated wit...
Detailed Description
During the COVID-19 pandemic a minority of children have presented to acute services with clinical features of a new syndrome known as Paediatric Inflammatory Multisystem Syndrome temporally associate...
Eligibility Criteria
Inclusion
- Within the age range of 3 months to ≤16 years
- Presenting clinically to non-ICU paediatric acute services at hospitals in the East of England region with symptoms suggestive of PIMS (e.g. incomplete Kawasaki's disease/Toxic Shock Syndrome) i.e. having: persistent fever (\>38.0oC for 5 or more days) AND high CRP (\>80) AND with one or more of additional features listed in Appendix 1 of the RCPCH document 'Guidance: paediatric multisystem inflammatory syndrome temporarily associated with COVID-19'
- Having either a positive or negative SARS-Cov-2 PCR test
Exclusion
- Aged below 3 months old or above 16 years old
- Confirmation of any microbial cause other than SARS-Cov-2 (including bacterial sepsis, staphylococcal or streptococcal shock syndromes, infections associated with myocarditis such as enterovirus). Determination of such microbial causes is by routine testing i.e. blood culture; pneumococcal, meningococcal, group A strep, staph aureus blood PCR; ASOT; EBV, CMV, adenovirus, enterovirus PCR on blood; urine and stool culture; throat swab culture; stool virology.
Key Trial Info
Start Date :
June 22 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2021
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04761913
Start Date
June 22 2021
End Date
December 31 2021
Last Update
February 9 2022
Active Locations (6)
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1
Mid Essex Hospital Trust
Chelmsford, Essex, United Kingdom, CM1 7ET
2
East Suffolk and north Essex NHS Foundation Trust
Colchester, Essex, United Kingdom, CO4 5JL
3
The Princess Alexandra Hospital NHS Trust
Harlow, Essex, United Kingdom, CM20 1QX
4
James Paget University Hospitals NHS Foundation Trust
Great Yarmouth, Norfolk, United Kingdom, NR31 6LA