Status:
COMPLETED
Pain, Learning, and Nocebo
Lead Sponsor:
Leiden University Medical Center
Collaborating Sponsors:
Leiden University
Conditions:
Chronic Pain
Pain Syndrome
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
Nocebo effects, negative responses to inert or active treatments which are putatively induced by negative outcome expectations, have been shown to play a significant role in pain perception. The under...
Detailed Description
Main outcome variable: \- The magnitude of induced nocebo hyperalgesia is defined as the difference in pain ratings for the first nocebo trial compared to the first control trial of the extinction ph...
Eligibility Criteria
Inclusion
- Aged 18 - 35 years
- Good understanding of the English language
- Normal or corrected to normal vision
Exclusion
- A potential participant who meets any of the following exclusion criteria will be excluded from participation in this study:
- History of serious or chronic medical or psychiatric conditions (e.g., convulsions (epilepsy), cardiovascular problems, depression; careful and detailed screening will be carried out for both medical and psychiatric conditions)
- History of chronic pain or itch conditions
- Experiencing pain or itch of 1 or more on a 0-10 pain / itch NRS on the day of testing
- Currently using antihistamines, analgesic medication, or itch-reducing medication (in the 24 hours prior to testing)
- Use of psychotropic drugs (including recreational drugs such as cannabis and psychotropic prescription-medication; in the past month)
- Currently being (or intending to become) pregnant, or currently breastfeeding, or planning to father a child in the next 3 months
- Colour-blindness
- Body Mass Index under 16 or over 30
- Meeting any exclusion criteria in the fMRI examination questionnaire which would prohibit fMRI scanning.
- Having too high of a threshold for pain (where high pain cannot be induced with temperatures lower than 49.5 °C).
Key Trial Info
Start Date :
February 28 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 20 2021
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT04762836
Start Date
February 28 2021
End Date
August 20 2021
Last Update
January 11 2022
Active Locations (1)
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1
Leiden University
Leiden, South Holland, Netherlands, 2333 AK